Regulating microRNA expression - at the heart of diabetes mellitus and the mitochondrion.pdf (627.36 kB)
Regulating microRNA expression - at the heart of diabetes mellitus and the mitochondrion.pdf
journal contributionposted on 2019-03-05, 21:36 authored by Quincy A. Hathaway, Mark Pinti, Andrya J. Durr, Shanawar Waris, Danielle L. Shepherd, John M. Hollander
The purpose of this review is to outline how mitochondrial processes are regulated by miRNAs in the diabetic heart. Furthermore, we will highlight the regulatory mechanisms, such as epigenetics, exosomal transport, miRNA processing, and posttranslational sequestration, that participate as regulators of miRNA expression. Additionally, current and future treatment strategies targeting dysfunctional mitochondrial processes in the diseased myocardium, as well as emerging miRNA-based
therapies, will be summarized.