Quincy A Hathaway - Genomics Highlight EB 2018 - Talk_FINAL_jh.pptx

Our results suggest that during type 2 diabetes mellitus, nuclear-encoded proteins that comprise the mitochondrial proteome and are involved in protein and RNA import can be epigenetically altered. Mitochondrial subpopulations also differentially express RNA during diabetic insult, with the SSM being more detrimentally impacted. Epigenetic alterations, and changes in RNA, reveal how environmental changes to the nuclear genome could shape mitochondrial structure and function.