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mitoTev‐TALE: a monomeric DNA editing enzyme to reduce mutant mitochondrial DNA levels
journal contribution
posted on 2019-04-07, 18:43 authored by Claudia V Pereira, Sandra R Bacman, Tania Arguello, Ugne Zekonyte, Sion L Williams, David R Edgell, Carlos T MoraesThis work describes the development of a mitochondrial‐targeted DNA editing enzyme that can specifically cleave the MERRF m.8344A>G mtDNA mutation. The novel feature of this enzyme is that it is monomeric, in contrast to mitoTALEN and mitoZFN, which are heterodimeric.
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- Biochemistry and cell biology not elsewhere classified
- Genetics not elsewhere classified
- Plant cell and molecular biology
- Animal cell and molecular biology
- Bioinformatic methods development
- Bioinformatics and computational biology not elsewhere classified
- Other biological sciences not elsewhere classified
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