s41598-018-28743-w.pdf (1.03 MB)

s41598-018-28743-w.pdf

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journal contribution
posted on 08.03.2019, 23:28 by Hanyu Zhang, Gregory P. Walcott, Jack Rogers
Mechanical stretch may play a role in initiating arrhythmia in heart via the activation of stretch-activated channels (SACs). To investigate the role of mechanical stretch, SAC blockers were used previously. Gadolinium (Gd3+) was a potential SAC blocker. However, in previous studies the effect of Gd3+ was not consistent. Thus, we tested the effect of Gd3+ on inhibiting cardiac mechano-sensitivity in a isolated pig heart model. The results show that Gd3+ cannot inhibit cardiac mechano-sensitivity in isolated pig hearts and thus using it to probe the role of mechanical stimulation in whole heart preparations should be done with great caution.

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Grant ID

16PRE30980044