s41598-018-28743-w.pdf (1.03 MB)
0/0

s41598-018-28743-w.pdf

Download (1.03 MB)
journal contribution
posted on 08.03.2019 by Hanyu Zhang, Gregory P. Walcott, Jack Rogers
Mechanical stretch may play a role in initiating arrhythmia in heart via the activation of stretch-activated channels (SACs). To investigate the role of mechanical stretch, SAC blockers were used previously. Gadolinium (Gd3+) was a potential SAC blocker. However, in previous studies the effect of Gd3+ was not consistent. Thus, we tested the effect of Gd3+ on inhibiting cardiac mechano-sensitivity in a isolated pig heart model. The results show that Gd3+ cannot inhibit cardiac mechano-sensitivity in isolated pig hearts and thus using it to probe the role of mechanical stimulation in whole heart preparations should be done with great caution.

History

Grant ID

16PRE30980044

Licence

Exports