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mitoTev‐TALE: a monomeric DNA editing enzyme to reduce mutant mitochondrial DNA levels

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journal contribution
posted on 2019-04-07, 18:43 authored by Claudia V Pereira, Sandra R Bacman, Tania Arguello, Ugne Zekonyte, Sion L Williams, David R Edgell, Carlos T Moraes
This work describes the development of a mitochondrial‐targeted DNA editing enzyme that can specifically cleave the MERRF m.8344A>G mtDNA mutation. The novel feature of this enzyme is that it is monomeric, in contrast to mitoTALEN and mitoZFN, which are heterodimeric.


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