mitoTev‐TALE: a monomeric DNA editing enzyme to reduce mutant mitochondrial DNA levels

Pereira, Claudia V; Bacman, Sandra R; Arguello, Tania; Zekonyte, Ugne; Williams, Sion L; Edgell, David R; Moraes, Carlos T

doi:10.25376/hra.7963679.v1

e8084.full.pdf (998.56 kB)

mitoTev‐TALE: a monomeric DNA editing enzyme to reduce mutant mitochondrial DNA levels

journal contribution

posted on 2019-04-07, 18:43 authored by Claudia V Pereira, Sandra R Bacman, Tania Arguello, Ugne Zekonyte, Sion L Williams, David R Edgell, Carlos T Moraes

This work describes the development of a mitochondrial‐targeted DNA editing enzyme that can specifically cleave the MERRF m.8344A>G mtDNA mutation. The novel feature of this enzyme is that it is monomeric, in contrast to mitoTALEN and mitoZFN, which are heterodimeric.