mitoTev‐TALE: a monomeric DNA editing enzyme to reduce mutant mitochondrial DNA levels
journal contributionposted on 07.04.2019 by Claudia V Pereira, Sandra R Bacman, Tania Arguello, Ugne Zekonyte, Sion L Williams, David R Edgell, Carlos T Moraes
Any type of content formally published in an academic journal, usually following a peer-review process.
This work describes the development of a mitochondrial‐targeted DNA editing enzyme that can specifically cleave the MERRF m.8344A>G mtDNA mutation. The novel feature of this enzyme is that it is monomeric, in contrast to mitoTALEN and mitoZFN, which are heterodimeric.