Health Research Alliance
Browse
TiCB_22.pdf (1.2 MB)

TiCB_22.pdf

Download (1.2 MB)
journal contribution
posted on 2023-01-10, 19:46 authored by Subramanian Sundaram, Chris Chen

Engineered microsystems for in vitro studies of cultured cells are evolving from simple 2D platforms to 3D architectures and organoid cultures. Despite advances

in reproducing ever more sophisticated biology in these systems, there remain foundational challenges in re-creating key aspects of tissue composition, architecture, and mechanics that are critical to recapitulating in vivo

processes. Against the backdrop of current progress in 3D fabrication methods, we evaluate the key requirements for the next generation of cellular platforms. We postulate that these future platforms – apart from building tissue-like structures – will need to have the ability to readily sense and autonomously modulate tissue responses over time, as occurs in natural microenvironments. Such interactive robotic platforms that report and guide cellular events will enable us to probe a previously inaccessible class of questions in cell biology.

History

Grant ID

20POST35210045

Usage metrics

    American Heart Association

    Licence

    Exports

    RefWorks
    BibTeX
    Ref. manager
    Endnote
    DataCite
    NLM
    DC