Sub-Toxic Human Amylin Fragment Concentrations.pdf (1.05 MB)
Download fileSub-Toxic Human Amylin Fragment Concentrations Promote the Survival and Proliferation of SH-SY5Y Cells via the Release of VEGF and HspB5 from Endothelial RBE4 Cells
journal contribution
posted on 2019-03-07, 10:58 authored by Giuseppe Caruso, Claudia G. Fresta, Giacomo Lazzarino, Donatella A. Distefano, Paolo Parlascino, Susan M. Lunte, Giuseppe Lazzarino, Filippo CaraciThis study demonstrated
that amylin (and beta-amyloid) might play an important physiological role in
promoting the release of neuroprotective factors, namely HspB5 and VEGF, from
endothelial cells of the capillary neurovasculature. The data presented in this
study confirm the existence of a “cross-talk” between endothelial and
neuron-like cells and the relevance of a physiological role of amylin and beta-amyloid,
such as the ability to promote the release of neuroprotective factors from
endothelial cells.