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Sleep Apnea, Hypoxia Inducible Factor, and Fatty Liver: More Questions Than Answers?

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posted on 2023-01-27, 16:46 authored by Lenise KimLenise Kim, Luu V. Pham, Vsevolod Y. Polotsky

HIF-1 and HIF-2 may mediate nonalcoholic fatty liver disease  severity and the progression to nonalcoholic steatohepatitis (NASH) as a result of tissue hypoxia in hepatic steatosis. In this context, conditions that expose patients to hypoxia could increase the risk for hepatic fibrosis and NASH.

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AHA Postdoctoral Fellowship Award 828142

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