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Pre-mRNA mis-splicing of sarcomeric genes in heart failure

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journal contribution
posted on 2019-03-03, 18:12 authored by Chaoqun Zhu, Zhilong Chen, Wei Guo

Pre-mRNA splicing is an important biological process that allows production of multiple proteins from a single gene in the genome, and mainly contributes to protein diversity in eukaryotic organisms. Alternative splicing is commonly governed by RNA binding proteins to meet the ever-changing demands of the cell. However, the mis-splicing may lead to human diseases. In the heart of human, mis-regulation of alternative splicing has been associated with heart failure. In this short review, we focus on alternative splicing of sarcomeric genes and review mis-splicing related heart failure with relatively well studied Sarcomeric genes and splicing mecha- nisms with identified regulatory factors. The perspective of alternative splicing based therapeutic strategies in heart failure has also been discussed.


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