PKM2 Blood.pdf

Nayak, Manasa; Ghatge, Madankumar; Flora, Gagan D.; Dhanesha, Nirav; Jain, Manish; Markan, Kathleen R.; Potthoff, Matthew J.; R. Lentz, Steven; Chauhan, Anil K.

doi:10.25376/hra.21865758.v1

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PKM2 Blood.pdf

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posted on 2023-01-11, 16:47 authored by Manasa Nayak, Madankumar Ghatge, Gagan D. Flora, Nirav Dhanesha, Manish Jain, Kathleen R. Markan, Matthew J. Potthoff, Steven R. Lentz, Anil K. Chauhan

Key Points:

1. Platelet activation increases PKM2 dimer

formation, which modulates platelet

functions and arterial thrombosis.

2. PKM2 regulates PI3Kmediated

Akt and

GSK3 signaling.

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Grant ID

19POST34410022

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Keywords

Platelet activation thrombosis Pyruvate kinase M2 Platelet metabolism

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CC BY 4.0

PKM2 Blood.pdf

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