Nally 2019 DTT Neo CGM Feasibility.pdf
Infants born to mothers with diabetes commonly experience asymptomatic hypoglycemia after
birth. Continuous glucose monitors (CGM) can detect asymptomatic hypoglycemia in this population without
the need for painful glucose checks. Sixteen infants were studied; 4 with a blinded CGM and 12 with remote monitoring (RM). When there
were confirmatory hospital glucometer readings, the sensitivity of the CGM to detect hypoglycemia was 86%
and the specificity was 91%. The positive predictive value was 55% and the negative predictive value was 98%.
In the full cohort, hypoglycemia (<45 mg/dL) was confirmed in 12 of 16 infants with 30 events at <12 hours of
life (HOL), 3 events between 12 and 24 HOL, and 1 event at >48 HOL. In the RM group, CGM detected
hypoglycemia five times when the infant was not due for a BG check based on the SOC. Overall, the CGM
detected five false-positive alerts and six true-positive alerts for hypoglycemia. Only one hypoglycemic episode
was missed by CGM in the RM group. Barriers to recruitment included fear of pain with glucose checks,
concerns with CGM use, satisfaction with the hospital SOC, personal reasons independent of the study, and lack
of interest in participating in research.