Mitochondrial proteome disruption in the diabetic heart through targeted epigenetic regulation at the mitochondrial heat shock protein 70 (mtHsp70) nuclear locus.pdf

L. Shepherd, Danielle; Hathaway, Quincy A.; E. Nichols, Cody; Durr, Andrya J.; Pinti, Mark; Hughes, Kristen; Kunovac, Amina; Stine, Seth; M. Hollander, John

doi:10.25376/hra.7806200.v1

Mitochondrial proteome disruption in the diabetic heart through targeted epigenetic regulation at the mitochondrial heat shock protein 70 (mtHsp70) nuclear locus.pdf (2.85 MB)

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Mitochondrial proteome disruption in the diabetic heart through targeted epigenetic regulation at the mitochondrial heat shock protein 70 (mtHsp70) nuclear locus.pdf

journal contribution

posted on 2019-03-05, 21:36 authored by Danielle L. Shepherd, Quincy A. Hathaway, Cody E. Nichols, Andrya J. Durr, Mark Pinti, Kristen Hughes, Amina Kunovac, Seth Stine, John M. Hollander

The goal of this study was to manipulate the mitochondrial protein import process through targeted restoration of mtHsp70, in an effort to restore proteomic signature and mitochondrial function in the T2DM heart.