Carnosine Prevents Abeta-Induced Oxidative Stress and Inflammation in Microglia.pdf (2.17 MB)
Download fileCarnosine prevents Aβ-induced oxidative stress and inflammation in microglial cells: a key role of TGF-β1
journal contribution
posted on 2019-03-07, 09:53 authored by Giuseppe Caruso, Claudia G. Fresta, Nicolò Musso, Mariaconcetta Giambirtone, Margherita Grasso, Simona F. Spampinato, Sara Merlo, Filippo Drago, Giuseppe Lazzarino, Maria Angela Sortino, Susan M. Lunte, Filippo CaraciBy using an in vitro model of AD, we showed
that carnosine prevents Aβ-induced oxidative stress in BV-2 microglial cells by
decreasing the expression of iNOS and NADPH oxidase and the concentrations of
nitric oxide and superoxide anion. Carnosine is also able to decrease the
secretion of pro-inflammatory cytokines, simultaneously rescuing IL-10 levels
and increasing the synthesis and the release of TGF-β1. Carnosine, through its
multimodal mechanism of action, might represent a new pharmacological tool to
yield neuroprotection in AD.
