Atlas of Exosomal microRNAs Secreted From Human iPSC-Derived Cardiac Cell Types

Cardiac-derived exosomes have received intense interest for their roles in para- crine communications and regenerative therapies. However, current under- standing of how exosomes mediate cellular signaling is incomplete, in part because the contents of exosomes from different cardiac cell types are poorly de- fined. To learn what signals cardiac cells release, we examined the microRNA (miR- NA) compositions secreted in exosomes from human induced pluripotent stem 

cells (iPSCs) and 3 major iPSC-derived cardiac cell types.