Articulo 022 Total Chemical Synthesis of HKE2.pdf (785.21 kB)
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Articulo 022 Total Chemical Synthesis of HKE2.pdf

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journal contribution
posted on 14.04.2019, 21:36 authored by Robert E. Boer, Juan Antonio Gimenez-Bastida, Claus Schneider, Gary A. Sulikowski, Somnath Jana, Olivier Boutaud
The total synthesis of hemiketal E2 (HKE2) has been accomplished using a gold(I)-mediated cycloisomerization followed by oxidation of the enol ether product to introduce a unique keto-hemiketal, the core structure of HKE2. Synthetic hemiketal E2 reproduced biosynthetically derived HKE2 in the inhibition of human platelet aggregation

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Grant ID

Postdoctoral award from the American Heart Association (16POST30690001)