Articulo 022 Total Chemical Synthesis of HKE2.pdf

Boer, Robert
E.; Gimenez-Bastida, Juan Antonio; Schneider, Claus; Sulikowski, Gary A.; Jana, Somnath; Boutaud, Olivier

doi:10.25376/hra.7992563.v1

Articulo 022 Total Chemical Synthesis of HKE2.pdf (785.21 kB)

Articulo 022 Total Chemical Synthesis of HKE2.pdf

journal contribution

posted on 2019-04-14, 21:36 authored by Robert E. Boer, Juan Antonio Gimenez-Bastida, Claus Schneider, Gary A. Sulikowski, Somnath Jana, Olivier Boutaud

The total synthesis of hemiketal E2 (HKE2) has been accomplished using a gold(I)-mediated cycloisomerization followed by oxidation of the enol ether product to introduce a unique keto-hemiketal, the core structure of HKE2. Synthetic hemiketal E2 reproduced biosynthetically derived HKE2 in the inhibition of human platelet aggregation