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Stage 2 ET1.JAHA.2022.pdf (396.59 kB)
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20CDA35310498 Stage 2 ET1.JAHA.2022.pdf

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journal contribution
posted on 2023-07-03, 14:48 authored by Benjamin Frank, Jesse DavidsonJesse Davidson, Michael DiMaria


In this paper we demonstrated that endothelin-1 (ET1) is regulated in important ways in infants with SVHD compared to healthy controls. We also showed an association between failure to suppress ET1 level before and after Stage 2 palliation and multiple adverse clinical outcomes related to pulmonary hypertension including low oxygen saturations, need for targeted PH medication, and need for invasive cardiac catheterization within 3 months of surgery. This association remained significant in multivariable analysis controlling for several clinical variables.


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    American Heart Association