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Pre-mRNA mis-splicing of sarcomeric genes in heart failure

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journal contribution
posted on 09.04.2018 by Chaoqun Zhu, ZHilong Chen, Wei Guo

Pre-mRNA splicing is an important biological process that allows production of multiple proteins from a single

gene in the genome, and mainly contributes to protein diversity in eukaryotic organisms. Alternative splicing

is commonly governed by RNA binding proteins to meet the ever-changing demands of the cell. However, the

mis-splicing may lead to human diseases. In the heart of human, mis-regulation of alternative splicing has

been associated with heart failure. In this short review, we focus on alternative splicing of sarcomeric genes

and review mis-splicing related heart failure with relatively well studied Sarcomeric genes and splicing mechanisms

with identified regulatory factors. The perspective of alternative splicing based therapeutic strategies in

heart failure has also been discussed.


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