Non-toxic engineered carbon nanodiamond concentrations induce oxidative/nitrosative stress, imbalance of energy metabolism, and mitochondrial dysfunction in microglial and alveolar basal epithelial cells
journal contributionposted on 07.03.2019 by Claudia G. Fresta, Aishik Chakraborty, Manjula B. Wijesinghe, Angela M. Amorini, Giacomo Lazzarino, Giuseppe Lazzarino, Barbara Tavazzi, Susan M. Lunte, Filippo Caraci, Prajnaparamita Dhar, Giuseppe Caruso
Any type of content formally published in an academic journal, usually following a peer-review process.
The findings reported in this paper highlight the importance of investigating the modulation of energy metabolism as well as nitric oxide and ROS production at cellular level even at very low-dose, apparently non-toxic, nanoparticle concentrations. The present study indicates that a much better comprehension of the molecular and biochemical changes caused by the interaction of carbon nanoparticles (and nanoparticles in general) with living cells is mandatory before these highly promising tools might ﬁnd the correct application in the biomedical ﬁeld.