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JCBFM_Billinger2017.pdf

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journal contribution
posted on 11.03.2019 by Sandra A. Billinger, Jason-Flor V. Sisante, Eric D. Vidoni, Kiersten Kirkendoll, Jaimie Ward, Yumei Liu, Sarah J. Kwapiszeski, Rebecca Maletsky, Jeffrey M. Burns

The goal of this study was to explore the association of beta-amyloid accumulation andcerebrovascular response (CVR) in cognitively normal older adults. Beta-amyloid accumulation was characterized with [18F] Florbetapir positron emission tomography scans. CVR was calculated as middle cerebral artery blood flow velocity change from rest to moderate intensity exercise. We found that individuals with elevated beta-amyloid aggregation had a blunted CVR (n = 25, age 70.1 ± 4.8; 3.3 ± 3.7cm/s) compared to non-elevated individuals (n = 45,age 72.0 ± 4.9; 7.2 ± 5.0 cm/s,p < 0.001). Further, greater beta-amyloid burden was linearly associated with less CVR across all participants (b = -11.7, p<0.001). Greater CVR and less beta-amyloid burden were associated with Processing Speed (p<0.05). This study is the first to show that CVR from rest to exercise is blunted across increased global beta-amyloid burden.

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