Carnosine Prevents Abeta-Induced Oxidative Stress and Inflammation in Microglia.pdf (2.17 MB)

Carnosine prevents Aβ-induced oxidative stress and inflammation in microglial cells: a key role of TGF-β1

Download (2.17 MB)
journal contribution
posted on 07.03.2019 by Giuseppe Caruso, Claudia G. Fresta, Nicolò Musso, Mariaconcetta Giambirtone, Margherita Grasso, Simona F. Spampinato, Sara Merlo, Filippo Drago, Giuseppe Lazzarino, Maria Angela Sortino, Susan M. Lunte, Filippo Caraci
By using an in vitro model of AD, we showed that carnosine prevents Aβ-induced oxidative stress in BV-2 microglial cells by decreasing the expression of iNOS and NADPH oxidase and the concentrations of nitric oxide and superoxide anion. Carnosine is also able to decrease the secretion of pro-inflammatory cytokines, simultaneously rescuing IL-10 levels and increasing the synthesis and the release of TGF-β1. Carnosine, through its multimodal mechanism of action, might represent a new pharmacological tool to yield neuroprotection in AD.

History

Grant ID

NFP0075515 (16POST29720000)

Licence

Exports