Articulo 022 Total Chemical Synthesis of HKE2.pdf (785.21 kB)

Articulo 022 Total Chemical Synthesis of HKE2.pdf

Download (785.21 kB)
journal contribution
posted on 14.04.2019 by Robert E. Boer, Juan Antonio Gimenez-Bastida, Claus Schneider, Gary A. Sulikowski, Somnath Jana, Olivier Boutaud
The total synthesis of hemiketal E2 (HKE2) has been accomplished using a gold(I)-mediated cycloisomerization followed by oxidation of the enol ether product to introduce a unique keto-hemiketal, the core structure of HKE2. Synthetic hemiketal E2 reproduced biosynthetically derived HKE2 in the inhibition of human platelet aggregation

History

Grant ID

Postdoctoral award from the American Heart Association (16POST30690001)

Licence

Exports

Logo branding

Licence

Exports