Articulo 022 Total Chemical Synthesis of HKE2.pdf
journal contributionposted on 14.04.2019 by Robert E. Boer, Juan Antonio Gimenez-Bastida, Claus Schneider, Gary A. Sulikowski, Somnath Jana, Olivier Boutaud
Any type of content formally published in an academic journal, usually following a peer-review process.
The total synthesis of hemiketal E2 (HKE2) has been accomplished using a gold(I)-mediated cycloisomerization followed by oxidation of the enol ether product to introduce a unique keto-hemiketal, the core structure of HKE2. Synthetic hemiketal E2 reproduced biosynthetically derived HKE2 in the inhibition of human platelet aggregation