12974_2018_Article_1077.pdf (7.19 MB)

IRE1α inhibition decreased TXNIP/NLRP3 inflammasome activation through miR-17-5p after neonatal hypoxic–ischemic brain injury in rats

dataset

posted on 2019-03-21, 19:45 authored by Jiping Tang

IRE1a-induced UPR pathway may contribute to inflammatory activation and brain injury following neonatal HI. IRE1a activation, through decay of miR-17-5p, elevated TXNIP expression to activate NLRP3 inflammasome

and aggravated brain damage.

History

Grant ID

17GRNT33670031

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American Heart Association

Keywords

Hypoxia–ischemia, IRE1α, MicroRNA-17 (miR-17), Neonatal, Nod-like receptor protein 3 (NLRP3), Thioredoxin-interacting protein (TXNIP)Central Nervous System

Licence

CC BY 4.0