Toll-Like Receptors, Hypertension, and an Antimalarial Drug

2019-03-07T16:00:25Z (GMT) by Madhu V. Singh
The role of the immune system in the pathogenesis of hypertension
is a growing area of research. Although the immune
system had long been suspected to contribute to hypertension,
only in the last decade have studies begun to define the roles
of the participating immune cells and molecules involved in
hypertension.1–4 Toll-like receptors (TLRs)5,6 are part of the
innate immune system that recognize molecular patterns on
various pathogens (pathogen-associated molecular patterns)
and so called endogenous damage signals (damage-associated
molecular patterns). These patterns may be proteins, lipids,
carbohydrates, or nucleic acids. TLRs are expressed either on
the cell surface or in intracellular endolysosomal compartment.
Although the endogenous ligands of the TLRs that trigger
hypertension have not been identified, disruption of TLR
signaling has been shown to attenuate hypertension.