Toll-Like Receptors, Hypertension, and an Antimalarial Drug

2019-03-07T16:00:25Z (GMT) by Madhu V. Singh
The role of the immune system in the pathogenesis of hypertension<br>is a growing area of research. Although the immune<br>system had long been suspected to contribute to hypertension,<br>only in the last decade have studies begun to define the roles<br>of the participating immune cells and molecules involved in<br>hypertension.1–4 Toll-like receptors (TLRs)5,6 are part of the<br>innate immune system that recognize molecular patterns on<br>various pathogens (pathogen-associated molecular patterns)<br>and so called endogenous damage signals (damage-associated<br>molecular patterns). These patterns may be proteins, lipids,<br>carbohydrates, or nucleic acids. TLRs are expressed either on<br>the cell surface or in intracellular endolysosomal compartment.<br>Although the endogenous ligands of the TLRs that trigger<br>hypertension have not been identified, disruption of TLR<br>signaling has been shown to attenuate hypertension.