Pre-mRNA mis-splicing of sarcomeric genes in heart failure
Pre-mRNA splicing is an important biological process that allows production of multiple proteins from a single
gene in the genome, and mainly contributes to protein diversity in eukaryotic organisms. Alternative splicing
is commonly governed by RNA binding proteins to meet the ever-changing demands of the cell. However, the
mis-splicing may lead to human diseases. In the heart of human, mis-regulation of alternative splicing has
been associated with heart failure. In this short review, we focus on alternative splicing of sarcomeric genes
and review mis-splicing related heart failure with relatively well studied Sarcomeric genes and splicing mechanisms
with identified regulatory factors. The perspective of alternative splicing based therapeutic strategies in
heart failure has also been discussed.
History
Grant ID
16BGIA27790136Usage metrics
Categories
- Cardiology (incl. cardiovascular diseases)
- Biochemistry and cell biology not elsewhere classified
- Plant cell and molecular biology
- Animal cell and molecular biology
- Animal physiology - biophysics
- Animal physiology - cell
- Animal physiology - systems
- Pathology (excl. oral pathology)
- Oral medicine and pathology