BBA Mol Cell Biol l-Transcriptional brakes on the road to adipocyte thermogenesis.pdf

2019-03-04T22:01:42Z (GMT) by Mengle Shao Rana Gupta
<div>White adipocytes represent the principle site for energy storage whereas brown/beige adipocytes emerge from</div><div>seemingly distinct cellular lineages and burn chemical energy to produce heat. Thermogenic adipocytes utilize</div><div>cell-type selective master regulatory transcription factors to drive the expression of their adipocyte thermogenic</div><div>gene program. White adipocytes harbor transcriptional mechanisms to suppress the thermogenic gene program</div><div>and maintain an energy-storing function. Here, we summarize some of the key developmental and transcriptional</div><div>mechanisms leading to the postnatal recruitment of thermogenic adipocytes under physiological conditions,</div><div>with a particular emphasis on the transcriptional “brakes” on the thermogenic gene program. We highlight</div><div>a number of recent studies, including our own work on the transcription factor, ZFP423, that illustrate the</div><div>potential to engineer the subcutaneous and visceral white fat lineages to adopt a thermogenic fat cell fate by</div><div>releasing the inhibition of the adipocyte thermogenic gene program. These transcriptional brakes on adipocyte</div><div>thermogenesis may represent potential targets of therapeutic interventions designed to combat obesity and</div><div>associated metabolic disorders.</div>