A STRIPAK complex mediates axonal transport of autophagosomes and dense core vesicles through PP2A regulation.

Here we show that the STRIPAK complex regulates the transport of a subset of organelles, autophagosomes and dense core vesicles. We have found that the dynein motor complex is linked to one of its cargo, autophagosomes through the STRIPAK complex. The STRIPAK complex contains the phosphatase PP2A, and the activity of the phosphatase is essential to regulate the transport of both autophagosomes and dense core vesicles.