10.25376/hra.8115959.v1
Jiang Xie
Jiang
Xie
Anwar Chahal
Anwar
Chahal
Naima Covassin
Naima
Covassin
Phillip J. Schulte
Phillip J.
Schulte
Prachi Singh
Prachi
Singh
Narat Srivali
Narat
Srivali
Virend Somers
Virend
Somers
Sean Caples
Sean
Caples
Final_article_PLMS_prevalence_AF_IJC_2017.pdf
Health Research Alliance
2019
Sleep-disordered breathing
Atrial fibrillation
Periodic limb movements of sleep
Cardiology (incl. Cardiovascular Diseases)
2019-05-12 19:13:04
Journal contribution
https://hra.figshare.com/articles/journal_contribution/Final_article_PLMS_prevalence_AF_IJC_2017_pdf/8115959
<p>Background: Growing evidence indicates that periodic limb movements of sleep (PLMS) may be related to increased</p><p>risk of developing cardiovascular disease. However, the association of PLMS with atrial fibrillation (AF)</p><p>is unclear, especially in patientswith sleep-disordered breathing (SDB). This study sought to investigatewhether</p><p>PLMS were associated with increased AF prevalence, independent of established risk factors.</p><p>Methods: We performed a cross-sectional study of patients who underwent attended polysomnography atMayo</p><p>Clinic from2011 to 2014. The association of PLMSwith AF prevalence was estimated by using logistic regression</p><p>models.</p><p>Results: 15,414 patients were studied, 76.3% of individuals with SDB defined by apnea-hypopnea index</p><p>(AHI) ≥5/h, and 15.3% with a diagnosis of AF. In univariate logistic modelling, individuals with periodic</p><p>limb movement index (PLMI) ≥30/h had higher odds of AF (odds ratio [OR] 1.96, 95% confidence interval</p><p>[CI]1.79–2.16, p b 0.001) when compared to patients with PLMI b15/h. After multivariate adjustment (for</p><p>age, race, sex, history of smoking, hypertension, diabetes, coronary artery disease, heart failure, cerebrovascular</p><p>disease, renal disease, iron deficiency anemia, chronic obstructive pulmonary disease, AHI, arousal</p><p>index), inmild SDB patients, a PLMI ≥30/h or periodic limbmovement arousal index (PLMAI) ≥5/h had significantly</p><p>higher odds of AF than thosewith PLMI b15/h (OR 1.21, 95% CI 1.00–1.47, p=0.048) or PLMAI b1/h (OR 1.27, 95%</p><p>CI 1.03–1.56, p= 0.024).</p><p>Conclusions: Frequent PLMS are independently associated with AF prevalence in patients with mild SDB. Further</p><p>studies are needed to better understand the relationship with incident AF.</p>