10.25376/hra.8115959.v1 Jiang Xie Jiang Xie Anwar Chahal Anwar Chahal Naima Covassin Naima Covassin Phillip J. Schulte Phillip J. Schulte Prachi Singh Prachi Singh Narat Srivali Narat Srivali Virend Somers Virend Somers Sean Caples Sean Caples Final_article_PLMS_prevalence_AF_IJC_2017.pdf Health Research Alliance 2019 Sleep-disordered breathing Atrial fibrillation Periodic limb movements of sleep Cardiology (incl. Cardiovascular Diseases) 2019-05-12 19:13:04 Journal contribution https://hra.figshare.com/articles/journal_contribution/Final_article_PLMS_prevalence_AF_IJC_2017_pdf/8115959 <p>Background: Growing evidence indicates that periodic limb movements of sleep (PLMS) may be related to increased</p><p>risk of developing cardiovascular disease. However, the association of PLMS with atrial fibrillation (AF)</p><p>is unclear, especially in patientswith sleep-disordered breathing (SDB). This study sought to investigatewhether</p><p>PLMS were associated with increased AF prevalence, independent of established risk factors.</p><p>Methods: We performed a cross-sectional study of patients who underwent attended polysomnography atMayo</p><p>Clinic from2011 to 2014. The association of PLMSwith AF prevalence was estimated by using logistic regression</p><p>models.</p><p>Results: 15,414 patients were studied, 76.3% of individuals with SDB defined by apnea-hypopnea index</p><p>(AHI) ≥5/h, and 15.3% with a diagnosis of AF. In univariate logistic modelling, individuals with periodic</p><p>limb movement index (PLMI) ≥30/h had higher odds of AF (odds ratio [OR] 1.96, 95% confidence interval</p><p>[CI]1.79–2.16, p b 0.001) when compared to patients with PLMI b15/h. After multivariate adjustment (for</p><p>age, race, sex, history of smoking, hypertension, diabetes, coronary artery disease, heart failure, cerebrovascular</p><p>disease, renal disease, iron deficiency anemia, chronic obstructive pulmonary disease, AHI, arousal</p><p>index), inmild SDB patients, a PLMI ≥30/h or periodic limbmovement arousal index (PLMAI) ≥5/h had significantly</p><p>higher odds of AF than thosewith PLMI b15/h (OR 1.21, 95% CI 1.00–1.47, p=0.048) or PLMAI b1/h (OR 1.27, 95%</p><p>CI 1.03–1.56, p= 0.024).</p><p>Conclusions: Frequent PLMS are independently associated with AF prevalence in patients with mild SDB. Further</p><p>studies are needed to better understand the relationship with incident AF.</p>