10.25376/hra.7992563.v1 Robert E. Boer Robert E. Boer Juan Antonio Gimenez-Bastida Juan Antonio Gimenez-Bastida Claus Schneider Claus Schneider Gary A. Sulikowski Gary A. Sulikowski Somnath Jana Somnath Jana Olivier Boutaud Olivier Boutaud Articulo 022 Total Chemical Synthesis of HKE2.pdf Health Research Alliance 2019 platelet aggregation hemiketal E2 Eicosanoids Chemical synthesis arachidonic acid Organic Chemistry 2019-04-14 21:36:46 Journal contribution https://hra.figshare.com/articles/journal_contribution/Articulo_022_Total_Chemical_Synthesis_of_HKE2_pdf/7992563 The total synthesis of hemiketal E2 (HKE2) has been accomplished using a gold(I)-mediated cycloisomerization followed by oxidation of the enol ether product to introduce a unique keto-hemiketal, the core structure of HKE2. Synthetic hemiketal E2 reproduced biosynthetically derived HKE2 in the inhibition of human platelet aggregation