10.25376/hra.7992563.v1
Robert
E. Boer
Robert
E.
Boer
Juan Antonio Gimenez-Bastida
Juan Antonio
Gimenez-Bastida
Claus Schneider
Claus
Schneider
Gary A. Sulikowski
Gary A.
Sulikowski
Somnath Jana
Somnath
Jana
Olivier Boutaud
Olivier
Boutaud
Articulo 022 Total Chemical Synthesis of HKE2.pdf
Health Research Alliance
2019
platelet aggregation
hemiketal E2
Eicosanoids
Chemical synthesis
arachidonic acid
Organic Chemistry
2019-04-14 21:36:46
Journal contribution
https://hra.figshare.com/articles/journal_contribution/Articulo_022_Total_Chemical_Synthesis_of_HKE2_pdf/7992563
The total synthesis of hemiketal E2 (HKE2) has been accomplished using a gold(I)-mediated cycloisomerization followed by oxidation of the enol ether product to introduce a unique keto-hemiketal, the core structure of HKE2. Synthetic hemiketal E2 reproduced biosynthetically derived HKE2 in the inhibition of human platelet aggregation