10.25376/hra.7910399.v1 Andrés Caballero Andrés Caballero Wenbin Mao Wenbin Mao Liang Liang Liang Liang John N. Oshinski John N. Oshinski Charles Primiano Charles Primiano Raymond McKay Raymond McKay Susheel Kodali Susheel Kodali Wei Sun Wei Sun 2017-Modeling Left Ventricular Blood Flow Using Smoothed Particle Hydrodynamics.pdf Health Research Alliance 2019 Smoothed Particle Hydrodynamics cardiac magnetic resonance Computational fluid dynamics Left ventricle Biomechanical Engineering 2019-03-28 16:25:55 Journal contribution https://hra.figshare.com/articles/journal_contribution/2017-Modeling_Left_Ventricular_Blood_Flow_Using_Smoothed_Particle_Hydrodynamics_pdf/7910399 This study aims to investigate the capability of smoothed particle hydrodynamics (SPH), a fully Lagrangian mesh-free method, to simulate the bulk blood flow dynamics in two realistic left ventricular (LV) models. Three dimensional geometries and motion of the LV, proximal left atrium and aortic root are extracted from cardiac magnetic resonance imaging and multi-slice computed tomography imaging data. SPH simulation results are analyzed and compared with those obtained using a traditional finite volume-based numerical method, and to in vivo phase contrast magnetic resonance imaging and echocardiography data, in terms of the large-scale blood flow phenomena usually clinically measured. A quantitative comparison of the velocity fields and global flow parameters between the in silico models and the in vivo data shows a reasonable agreement, given the inherent uncertainties and limitations in the modeling and imaging techniques. The results indicate the capability of SPH as a promising tool for predicting clinically relevant large-scale LV flow information.