Non-toxic engineered carbon nanodiamond concentrations induce oxidative/nitrosative stress, imbalance of energy metabolism, and mitochondrial dysfunction in microglial and alveolar basal epithelial cells
Claudia G. Fresta
Aishik Chakraborty
Manjula B. Wijesinghe
Angela M. Amorini
Giacomo Lazzarino
Giuseppe Lazzarino
Barbara Tavazzi
Susan M. Lunte
Filippo Caraci
Prajnaparamita Dhar
Giuseppe Caruso
10.25376/hra.7813538.v1
https://hra.figshare.com/articles/journal_contribution/Non-toxic_engineered_carbon_nanodiamond_concentrations_induce_oxidative_nitrosative_stress_imbalance_of_energy_metabolism_and_mitochondrial_dysfunction_in_microglial_and_alveolar_basal_epithelial_cells/7813538
The findings reported in this paper highlight
the importance of investigating the modulation of energy metabolism as well as
nitric oxide and ROS production at cellular level even at very low-dose,
apparently non-toxic, nanoparticle concentrations. The present study indicates
that a much better comprehension of the molecular and biochemical changes
caused by the interaction of carbon nanoparticles (and nanoparticles in
general) with living cells is mandatory before these highly promising tools might
find the correct application in the biomedical field.
2019-03-07 10:51:00
Nanoparticles
ROS
Microglia
Oxidative stress
Nitrosative stress
Lung
Energy metabolism
Mitochondrial dysfunction
Carnosine
Biomaterials
Cell Biology
Cell Metabolism
Neuroscience
Pharmacology