Phylloquinone Intake Is Associated with Cardiac Structure and Function in Adolescents
Mary Katherine Douthit
Mary Ellen Fain
Josh Nguyen
Celestine Williams
Allison Jasti
Bernard Gutin
Norman K. Pollock
10.25376/hra.7806461.v1
https://hra.figshare.com/articles/journal_contribution/Phylloquinone_Intake_Is_Associated_with_Cardiac_Structure_and_Function_in_Adolescents/7806461
<h3>Abstract</h3><p><b>Background:</b> Associations between childhood vitamin K consumption and cardiac structure and function have not been investigated.<b>Objective:</b>
We determined associations between phylloquinone (vitamin K-1) intake
and left ventricular (LV) structure and function in adolescents.<b>Methods:</b>
We assessed diet with three to seven 24-h recalls and physical activity
(PA) by accelerometry in 766 adolescents (aged 14-18 y, 50% female, 49%
black). Fat-free soft tissue (FFST) mass and fat mass were measured by
dual-energy X-ray absorptiometry. LV structure [LV mass (g)/height (m)<sup>2.7</sup>
(LV mass index) and relative wall thickness] and function [midwall
fractional shortening (MFS) and ejection fraction] were assessed by
echocardiography. Associations were evaluated by comparing the LV
structure and function variables across tertiles of phylloquinone
intake. Prevalence and OR of LV hypertrophy (LV mass index >95th
percentile for age and sex) were also assessed by phylloquinone
tertiles.<b>Results:</b> The prevalence of LV hypertrophy progressively decreased across tertiles of phylloquinone intake (<i>P</i>-trend
< 0.01). Multinomial logistic regression-adjusting for age, sex,
race, Tanner stage, systolic blood pressure, FFST mass, fat mass,
socioeconomic status, PA, and intakes of energy, fiber, calcium, vitamin
C, vitamin D, and sodium-revealed that compared with the highest
phylloquinone intake tertile (reference group), the adjusted OR for LV
hypertrophy was 3.3 (95% CI: 1.2, 7.4) for those in the lowest
phylloquinone intake tertile. When LV structure variables were compared
across phylloquinone intake tertiles adjusting for the same covariates,
there were significant linear downward trends for LV mass index (6.5%
difference, tertile 1 compared with tertile 3) and relative wall
thickness (9.2% difference, tertile 1 compared with tertile 3; both <i>P</i>-trend
≤ 0.02). Conversely, significant linear upward trends across
phylloquinone intake tertiles were observed for MFS (3.4% difference,
tertile 1 compared with tertile 3) and ejection fraction (2.6%
difference, tertile 1 compared with tertile 3; both <i>P</i>-trend < 0.04).<b>Conclusion:</b>
Our adolescent data suggest that subclinical cardiac structure and
function variables are most favorable at higher phylloquinone intakes.</p>
2019-03-05 22:16:27
Cardiovascular Disease
Children
Echocardiography
Left Ventricular Hypertrophy
Left Ventricular Mass
Phylloquinone
Vitamin K
Cardiology
Medicine
Nutritional Physiology
Nutrition and Dietetics not elsewhere classified