10.25376/hra.7800743.v1
Mengle Shao
Mengle
Shao
Lavanya Vishvanath
Lavanya
Vishvanath
Napoleon Busbuso
Napoleon
Busbuso
Chelsea Hepler
Chelsea
Hepler
Bo Shan
Bo
Shan
Ankit Sharma
Ankit
Sharma
Shiuhwei Chen
Shiuhwei
Chen
Xinxin Yu
Xinxin
Yu
Yu An
Yu
An
Yi Zhu
Yi
Zhu
William Holland
William
Holland
Rana Gupta
Rana
Gupta
Nat Commun-De novo adipocyte differentiation from Pdgfrβ+ preadipocytes protects against pathologic visceral adipose expansion in obesity.pdf
Health Research Alliance
2019
Adipose tissue hyperplasia
Adipose tissue remodeling
Preadipocyte
Adipose mural cell
Metabolic Medicine
2019-03-04 22:01:42
Journal contribution
https://hra.figshare.com/articles/journal_contribution/Nat_Commun-De_novo_adipocyte_differentiation_from_Pdgfr_preadipocytes_protects_against_pathologic_visceral_adipose_expansion_in_obesity_pdf/7800743
<div>Pathologic expansion of white adipose tissue (WAT) in obesity is characterized by adipocyte</div><div>hypertrophy, inflammation, and fibrosis; however, factors triggering this maladaptive remodeling</div><div>are largely unknown. Here, we test the hypothesis that the potential to recruit new</div><div>adipocytes from Pdgfrβ+ preadipocytes determines visceral WAT health in obesity. We</div><div>manipulate levels of Pparg, the master regulator of adipogenesis, in Pdgfrβ+ precursors of</div><div>adult mice. Increasing the adipogenic capacity of Pdgfrβ+ precursors through Pparg overexpression</div><div>results in healthy visceral WAT expansion in obesity and adiponectin-dependent</div><div>improvements in glucose homeostasis. Loss of mural cell Pparg triggers pathologic visceral</div><div>WAT expansion upon high-fat diet feeding. Moreover, the ability of the TZD class of antidiabetic</div><div>drugs to promote healthy visceral WAT remodeling is dependent on mural cell Pparg.</div><div>These data highlight the protective effects of de novo visceral adipocyte differentiation in</div><div>these settings, and suggest Pdgfrβ+ adipocyte precursors as targets for therapeutic intervention</div><div>in diabetes.</div>